The high-affinity immunoglobulin receptor FcγRI potentiates HIV-1 neutralization via antibodies against the gp41 N-heptad repeat.

Proc Natl Acad Sci U S A · 2021 · PMC7826338 · PMID 33431684

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highly significantno p-value reported

Second, in a comprehensive meta-analysis of numerous passive immunization studies showing that serum-neutralization antibody titers associate with protection against SHIV challenge, mAbs targeting the MPER were a highly significant outlier compared with other neutralizing mAbs, with much greater potency than would be predicted from serum-neutralization titers measured in cell culture ( 53 ) (see also refs. 54 and 55 ).

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