Age by Single Nucleotide Polymorphism Interactions on Bronchodilator Response in Asthmatics.

J Pers Med · 2021 · PMC7833432 · PMID 33477890

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0500

boldest claim

The sentences

marginally significantp < 0.05actually significant

Considering candidate genes from two previous GWAS of BDR, three SNPs (rs10476900 (near ADRB2 ) [ p -value = 0.009], rs10827492 ( CREM ) [ p -value = 0.02], and rs72646209 ( NCOA3 ) [ p -value = 0.02]) had a marginally significant interaction with age on BDR ( p < 0.05).

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marginal significanceno p-value reported

Second, we then tested SNPs from prior GWAS studies for interaction with age in our cohort and three variants in the genes CREM , NCOA3 and near ADRB2 showed differential associations at a marginal significance level of 0.05 with BDR by age.

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