RNA sequence and ligand binding alter conformational profile of SARS-CoV-2 stem loop II motif.

Biochem Biophys Res Commun · 2021 · PMC7834705 · PMID 33545635

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highly significantno p-value reported

The SARS-CoV-2 stem-loop II motif conformational differences due to nucleotide transversion and ligand binding are highly significant and provide insight for future drug discovery efforts since the conformation of noncoding RNA elements affects their function.

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