Differential Progression of Motor Dysfunction Between Male and Female Fragile X Premutation Carriers Reveals Novel Aspects of Sex-Specific Neural Involvement.

Although the progress assessed by T2-T1 differences in cognitive scores, including the Pro-Rated IQ and the Wechsler subtests, was negligible in either sex, it was evident (and highly significant) for the SCL90 GSI (summary) score.

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We reported borderline significance of correlation between ICARS total and CGG in the male sample, but no significance with the gait or kinetic domains, possibly on account of extensive variability of these scores and the small sample size; a similar argument may apply to the CRST score, especially as they included the C domain of CRST, which is based on (highly subjective) reporting.

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