Insulin/IGF Axis in Breast Cancer: Clinical Evidence and Translational Insights.

Biomolecules · 2021 · PMC7835955 · PMID 33477996

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a positive trendno p-value reported

A recent clinical trial showed that metformin acts on BC tumor cell proliferation differently, with a positive trend toward inhibiting proliferation only in women with insulin resistance or higher BMI [ 51 ].

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borderline significantno p-value reported

Compared with normal weight women, significant or borderline significant increased risks of BC mortality were only observed for morbidly obese (≥40 kg/m 2 ) women and not for women in other obesity categories [ 38 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.