Homotypic and Heterotypic Protection and Risk of Reinfection Following Natural Norovirus Infection in a Highly Endemic Setting.

Significant evidence of heterotypic protection was observed among children with prior GII.4 infections, who exhibited a 48% reduction in the hazard of subsequent GI.3 infection (HR, 0.52; P = .005) and a trend of a 59% reduction in the hazard of subsequent GII.2 infections (HR, 0.41; P = .016) that failed to reach significance after correction for multiple comparisons.

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