Validity of Osteoprotegerin and Receptor Activator of NF-κB Ligand for the Detection of Bone Metastasis in Breast Cancer.

ROC curve analyses of the value of study markers in detecting bone metastasis showed that both markers were associated with a highly significant area under the curve of 0.77 and 0.72 for OPG and RANKL, respectively ( p < 0.001) ( Fig. 6 ).

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