Efficacy of a multivalent vaccine against Fasciola hepatica infection in sheep.

Although IgG2 was significantly elevated right after vaccination in all immunised animals ( p = 0.015), sheep from group 1 exhibited an increasing trend in the IgG2 level in contrast to animals from group 2.

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However, in some vaccine trials, a highly significant adjuvant effect could be demonstrated, as described using LAP as antigen, with a range of protection between 49.5% and 86.7% depending on the adjuvant used [ 21 ].

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