Further studies are needed to determine the optimal lead PPMO, as there was not a clear compound that was superior in these studies, although there was a slight trend toward improved in vitro and in vivo activity with 5′ peptide conjugates.
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Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers Retain Activity against Multidrug-Resistant Pseudomonas aeruginosa <i>In Vitro</i> and <i>In Vivo</i>.
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