borderline significancep = 0.06
In 12,654 patients from seven studies where multiple anticancer agents were used in the procedures, TACE was associated with a 25% reduction in hazard of death (HR = 0.75, 95% CI = 0.64–0.88, p = 0.0004), while in 436 patients from three studies that only used one anticancer agent, the reduction associated with TACE was smaller and of only borderline significance (HR = 0.83, 97% CI = 0.68–1.01, p = 0.06) but showed higher homogeneity ( I 2 = 0, p for heterogeneity = 0.66).