Barely Significant
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Hypertension and Alzheimer's disease: indirect effects through circle of Willis atherosclerosis.

Brain Commun · 2020 · PMC7846096 · PMID 33543127

Europe PMCDOI
1
hedged sentence
0.0510
closest p · 1.0× alpha
0.0510
boldest claim

The sentences

failed to achieve significanceP = 0.051so close (0.05 < p ≤ 0.1)
Along the indirect pathway, there were significant associations of circle of Willis atherosclerosis with neuritic plaques ( t = 3.140, P = 0.002, OR = 1.20) and NFTs ( t = 2.350, P = 0.019, OR = 1.14); however, associations of hypertension with circle of Willis atherosclerosis failed to achieve significance ( t = 1.952, P = 0.051, OR = 1.11), leading to non-significant indirect effects of diastolic blood pressure on neuritic plaques (OR = 1.01, 95% CI = 1.00–1.01) and NFTs (OR = 1.01, 95% CI = 1.00–1.01).

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