A pharmacogenetics study of platinum-based chemotherapy in lung cancer: <i>ABCG2</i> polymorphism and its genetic interaction with <i>SLC31A1</i> are associated with response and survival.

J Cancer · 2021 · PMC7847637 · PMID 33531973

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marginal significanceno p-value reported

By using logistic regression analysis (Table 2 ), we found that the A/G genotype of rs1871744, in under-dominant model, was significantly associated with poor response in the total cohort (OR 0.60; 95% CI 0.42-0.87; P = 0.006), and this association was of significantly marginal significance in either panel A or panel B.

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highly significantno p-value reported

In further stratification analysis for the joint effect, the association of combined genotype of rs1871744 A/G and rs2233914 G/A+A/A with poor response was highly significant in male patients (OR 0.20; 95% CI 0.10-0.42), patients older than 58 (OR 0.16; 95% CI 0.06-0.41), patients with ECOG PS 0-1 (OR 0.30; 95% CI 0.16-0.57), smoker patients (OR 0.25; 95% CI 0.11-0.54) and patients with squamous cell carcinoma (OR 0.14; 95% CI 0.04-0.53), which is largely consistent with the stratification spectrum of rs1871744.

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