DENT-seq for genome-wide strand-specific identification of DNA single-strand break sites with single-nucleotide resolution.

Genome Res · 2021 · PMC7849381 · PMID 33355294

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highly significantno p-value reported

Eight nicks, all originating from the same guide RNA, resulted in highly significant sequence coverage peaks ( Fig. 5 B), and single-nucleotide resolution was achieved using the mutational signal ( Fig. 5 C; Supplemental Fig.

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