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Systematic identification of non-coding somatic single nucleotide variants associated with altered transcription and DNA methylation in adult and pediatric cancers.

NAR Cancer · 2021 · PMC7849833 · PMID 33554123

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an overall trendno p-value reported
Our study observed an overall trend of non-coding SNVs resulting in more upregulation versus downregulation of nearby genes.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.