Barely Significant
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Glucosepane is associated with changes to structural and physical properties of collagen fibrils.

Matrix Biol Plus · 2019 · PMC7852203 · PMID 33543010

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hedged sentence
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The sentences

highly significantp < 0.001actually significant
Our results show a highly significant (p < 0.001) four-fold increase in glucosepane levels in the old group of donors compared to the young group for the Achilles and anterior tibialis tendon.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.