High-throughput small molecule screening reveals Nrf2-dependent and -independent pathways of cellular stress resistance.

However, among the 620 compounds in the bottom 90% for all three stressors in the cell screen, only 40 were in the top 10% for increased worm lifespan in the results of Ye and colleagues (6.5%), indicating a highly significant association between induction of cellular stress resistance and C. elegans longevity ( P < 0.0001, Fisher’s exact test).

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