DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics.

Interestingly, histone concentrations, and thus cellularity, increased from the inner to the outer compartments of the disc, and showed a highly significant decrease in aged discs compared to young discs across all compartments ( Figure 1J , Wilcoxon p=5.6 × 10 −4 ; Figure 1—figure supplement 4B ).

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