Neuronavigation-guided focused ultrasound for transcranial blood-brain barrier opening and immunostimulation in brain tumors.

Sci Adv · 2021 · PMC7864566 · PMID 33547073

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a positive trendno p-value reported

Carpentier and co-workers ( 44 , 45 ) used a skull-implanted pulsed ultrasound device, SonoCloud-1, to repeatedly open the BBB concomitant with intravenous carboplatin delivery and showed a positive trend in overall survival for patients with rGBM with clear BBB disruption in comparison to those with minimal BBB disruption.

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