The Drosophila Forkhead/Fox transcription factor Jumeau mediates specific cardiac progenitor cell divisions by regulating expression of the kinesin Nebbish.

Our results revealed highly significant synergistic genetic interactions between neb and polo for both symmetric cell divisions and earlier cell divisions ( P = 3.89 × 10 −4 and P = 1.00 × 10 −6 , respectively), but no significant interactions in the case of asymmetric cardiac progenitor cell divisions ( P = 0.117) (Figs. 5 a,d,e, 6 b, Supplementary Table S1 ).

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However, the increase in the frequency of asymmetric cell division defects in neb MI0225 / +; jumu Df(3R)Exel6157 / +double heterozygotes over the additive sum of those in the component neb MI0225 / +and jumu Df(3R)Exel6157 / +single heterozygotes is barely significant ( P = 0.0429) (Figs. 5 a–c, 6 a, Supplementary Table S1 ).

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Defects in Svp precursor-determining cell divisions are also rescued, albeit with borderline significance ( P = 0.0632).

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