The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis.

Nat Commun · 2021 · PMC7865055 · PMID 33547282

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closest p · 0.0× alpha

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boldest claim

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highly significantP < 2.0 × 10 −16actually significant

We repeated linear regression analyses for the top significant CpGs in RUNX1 (cg12477880) and FLI1 (cg17239923), genes that are known regulators of hematopoiesis, adjusting for deconvoluted blood cell proportions instead of ReFACTor components (see “Methods”), and the associations with DS remained highly significant (both P < 2.0 × 10 −16 ).

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