Territory-wide cohort study of Brugada syndrome in Hong Kong: predictors of long-term outcomes using random survival forests and non-negative matrix factorisation.

From the study by Sieira et al (n=269), QRS duration and sinus node dysfunction were significant predictors, with atrial fibrillation showing a borderline significance. 5 QRS in lead V2 ≥113 ms and fragmented QRS complexes were identified as significant predictors by Letsas et al , 19 whereas S-wave (≥0.1 mV and/or≥40 ms) in lead I was proposed by Calò et al . 25 These studies illustrate the importance of depolarisation abnormalities in the form of slowed conduction and increased heterogeneity in conduction in promoting arrhythmogenesis.

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