AKT1-CREB stimulation of PDGFRα expression is pivotal for PTEN deficient tumor development.

Cell Death Dis · 2021 · PMC7876135 · PMID 33568640

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highly significantno p-value reported

For example, in a randomized phase II study, olaratumab, a human monoclonal antibody specific for PDGFRα, plus doxorubicin achieved a highly significant improvement in overall survival versus doxorubicin alone in patients with advanced or metastatic soft-tissue sarcoma 49 .

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