The highly significant induction of Spp1 in retinal microglia points to this gene as a key mediator of CNV pathology, which could be functionally associated with three major hallmarks of the CNV model: angiogenesis, macrophage recruitment, and tissue remodeling of the extracellular matrix (Tobe et al., 1998 ; Lambert et al., 2013 ).
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Secreted Phosphoprotein 1 Expression in Retinal Mononuclear Phagocytes Links Murine to Human Choroidal Neovascularization.
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