Validation of diagnostic codes and epidemiologic trends of Huntington disease: a population-based study in Navarre, Spain.

Orphanet J Rare Dis · 2021 · PMC7877055 · PMID 33568143

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an increasing trendno p-value reported

On average, three new HD positive cases were identified per year throughout the study period (1991–2017), 2.3 symptomatic and 0.7 asymptomatic (Table 2 ), showing an increasing trend of pre-manifest testing in detriment of the symptomatic.

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