The IL-33/ST2 axis affects tumor growth by regulating mitophagy in macrophages and reprogramming their polarization.

Because the OCR increased in IL-33 overexpressing BMDMs while the ECAR decreased, these macrophages presented an increased OCR to ECAR ratio ( P < 0.05) ( Figure 4F ), whereas the ECAR showed a decreasing trend ( P < 0.05) ( Figure 4G ), and the ratio of OCR to ECAR increased ( P < 0.05) ( Figure 4H ).

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