Effect of SLCO1B1 Polymorphisms on High-Dose Methotrexate Clearance in Children and Young Adults With Leukemia and Lymphoblastic Lymphoma.

The effect of the 388G allele in these studies was largest in patients with at least one copy of the 521T>C variant allele, and there was a slight trend toward progressively increased clearance with each copy of the 388G allele, although clearance values for the 388AG and 388GG genotypes within each 521T>C genotype were overall similar. 7,11 Similarly, we found that for subjects with at least one variant 521T>C allele, those with the 388AG or 388GG genotype had increased clearance compared with 388AA, 15% and 13% increase from that of 388AA, respectively, with the heterozygous and homozygous variant subjects having similar clearance values ( Figure 3c ).

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