Immunogenicity and crossreactivity of antibodies to the nucleocapsid protein of SARS-CoV-2: utility and limitations in seroprevalence and immunity studies.

IgG responses to OC43 N protein correlated the least to IgG to SARS-CoV-2 N protein in the rest of analyses, although it had a highly significant correlation with IgG to N from the alpha-HCoV 229E and NL63, in contrast to other reports. 64 Interestingly, in samples from rRT-PCR negative pandemic individuals, there was a significant inverse correlation of IgG to N from SARS-CoV-2 with IgG to N from OC43 HCoV that is the beta-HCoV with the highest sequence homology with SARS-CoV-2 N protein, suggesting a potential role on immunity.

also in 132,142 other papers