highly significantP < 0.0001
3 the ORs were highly significant for making a diagnosis of multiple sclerosis for the IEPD (OR 1.13, 95%CI 1.1–1.16, P < 0.0001, Fig. 3A ) and the IEAD (OR 1.16, 95%CI 1.13–1.2, P < 0.0001, Fig. 3B ) compared to the control cohorts ( Table 1 ).