Insertion-sequence-mediated mutations both promote and constrain evolvability during a long-term experiment with bacteria.

Nat Commun · 2021 · PMC7881107 · PMID 33579917

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highly significantp < 10 −5actually significant

This difference is highly significant (two-proportion z -test, p < 10 −5 ), and it yields a ratio for the fixation rate of IS-related mutations per generation in mutator versus non-mutator lines of 0.46.

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