Amylin deposition activates HIF1α and 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3 (PFKFB3) signaling in failing hearts of non-human primates.

Interestingly, we observed a highly significant positive correlation between serum amylin level and that of the ventricular remodeling and hypertrophy marker, ST2 (Fig. 3c ), but not with cTnI and GDF15 (Fig. 3d, e).

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