Unlike dietary restriction, rapamycin fails to extend lifespan and reduce transcription stress in progeroid DNA repair-deficient mice.

Compared to WT animals, Ercc1 ∆/− mice showed a highly significant bias for large genes to be underrepresented in the category of genes showing increased expression and overrepresented in the class of genes with reduced expression (Figure 5b,c ; gray solid versus black dashed lines; see arrows; and Table S3 ).

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