GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background.

Elife · 2021 · PMC7884075 · PMID 33587031

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highly significantno p-value reported

Additional highly significant hits that are not directly involved in the growth hormone–IGF pathway include the liver transcription factor HNF1A (also associated with urate [ Tin et al., 2019 ]); variants near two genes–GCKR and KLF14–that are involved in many biomarkers, although to our knowledge the mechanism is unclear; and variants at two additional genes CENPW and ZNF644.

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