CYP3A7*1C allele: linking premenopausal oestrone and progesterone levels with risk of hormone receptor-positive breast cancers.

7 None of the variants that we tested was associated with urinary pregnanediol-3-glucuronide, but a rare haplotype, defined by two SNPs spanning the cytochrome P450 family 3 subfamily A ( CYP3A ) gene cluster, was associated with a highly significant 32% difference in urinary oestrone-3-glucuronide. 4 Fine-scale mapping analyses identified the SNP rs45446698 as a putative causal variant at this locus; rs45446698 is one of seven highly correlated SNPs that cluster within the CYP3A7 promoter and comprise the CYP3A7*1C allele. 8 A genome-wide asso

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