Delineating the Genetic Component of Gene Expression in Major Depression.

Second, from these highly significant genes, we identified the genes that were colocalized (PP4 > .8) and likely to be causal (PIP > .5).

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This process identifies which features represent independent associations (termed jointly significant) and which features are not significant when accounting for the predicted expression of other features in the region (termed marginally significant) ( Supplement 1 ) ( 8 ).

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