Immunoscore is a standardized consensus scoring-system based on densities of two lymphocyte populations (CD3, CD8) infiltrating the tumor (CT) and invasive margin (IM) that has a highly significant prognostic value, and that has been introduced into cancer classification (WHO classification of Digestive System Tumors) and into clinical guidelines (ESMO). 1 , 2 The immune contexture parameters are associated with long-term survival and prediction of response to treatments. 8 We first described three major immune coordination profiles (hot, altered, cold) observed within primary CRCs, thus classified according to the balance between tumor escape and immune coordination.
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