Free CA125 promotes ovarian cancer cell migration and tumor metastasis by binding Mesothelin to reduce DKK1 expression and activate the SGK3/FOXO3 pathway.

Int J Biol Sci · 2021 · PMC7893585 · PMID 33613114

Europe PMC DOI

hedged sentences

—

closest p

—

boldest claim

The sentences

a decreasing trendno p-value reported

The Akt, p-Akt, PI3K, and SGK3 protein levels in total cells were not significantly changed; however, the content of FOXO3 in the nucleus had a decreasing trend.

also in 47,180 other papers

an increasing trendno p-value reported

The expression of SGK3 had an increasing trend, and FOXO3 translocated from the nucleus to the cytosol in siDKK1 cells synergistically with CA125 stimulation (Figure 5 C-D).

also in 63,971 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.