Assessing optimal: inequalities in codon optimization algorithms.

BMC Biol · 2021 · PMC7893858 · PMID 33607980

Europe PMC DOI

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantp < 1E−05actually significant

Relative to the codon frequency of the native DNA, the Mann-Whitney-Wilcox rank-sum analysis of the optimized CDSs shows that two are non-significantly (n.s.) optimized, four exhibit a p value between 1.4E−03 and 7.7E−04, and three are highly significant with a p < 1E−05 (GenScript, GeneArt, COOL).

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