The complex architecture of p53 binding sites.

The difference between LR and RLminus, and between RL and RLminus, is large, highly significant, and exists at all p53 concentration levels (Figure 4 , Supplementary Tables S3 and S4 ), though, as with LR versus RL, the difference is higher at low p53 concentration (0.002% galactose, t = 10.99 and 6.92, for LR-RLminus and RL-RLminus, respectively, P < 0.000001).

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