Safety, Tolerability, and Pharmacokinetics of Ibuprofenamine Hydrochloride Spray (NSAIDs), a New Drug for Rheumatoid Arthritis and Osteoarthritis, in Healthy Chinese Subjects.

Drug Des Devel Ther · 2021 · PMC7897713 · PMID 33628011

Europe PMC DOI

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a decreasing trendno p-value reported

A decreasing trend of blood sodium was apparent on day 6, with blood sodium levels returning to normal after 3 days.

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an increasing trendno p-value reported

In the SAD study for the first dose group (35 mg), an increasing trend of bilirubin and uric acid levels were apparent on day 6, with bilirubin and uric acid levels returning to normal after 3 days.

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