highly significantp<0.001
pneumoniae isolates we sequenced, 50 of the 51 SNPs detected were C•G-to-T•A transitions, and each of these was located in the 5′-TC-3′ context preferred by DddA ( Mok et al., 2020 ), a highly significant enrichment compared to spontaneous mutation patterns (p<0.001) ( Lee et al., 2012 ).