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Alzheimer's disease: from basic science to precision medicine approach.

BMJ Neurol Open · 2020 · PMC7903168 · PMID 33681801

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a positive trendno p-value reported
In some circumstances, the biomarker changes during the trial indicated a positive trend, although the clinical outcome was unsatisfactory.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.