A KDM6 inhibitor potently induces ATF4 and its target gene expression through HRI activation and by UTX inhibition.

Sci Rep · 2021 · PMC7907191 · PMID 33633164

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may be significantno p-value reported

Thus, even without the UTX mutations, anomalies affecting UTX expression levels such as haploinsufficiency and DNA methylation in the promoter region may be significant contributors to cancer formation 9 .

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