Radiological dynamics and SITC-defined resistance types of advanced melanoma during anti-PD-1 monotherapy: an independent single-blind observational study on an international cohort.

J Immunother Cancer · 2021 · PMC7908917 · PMID 33632901

Europe PMC DOI

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closest p · 1.8× alpha

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boldest claim

The sentences

marginal significancep=0.09so close (0.05 < p ≤ 0.1)

However, no significant correlation was found between baseline characteristics and PPS ( online supplemental table 13 ), although BRAF mutation seemed to be a protective factor with marginal significance towards longer PPS (HR 0.630, 95% CI 0.368 to 1.080, p=0.09) with targeted therapy as a second-line regimen after PD from anti-PD-1 monotherapy for these subgroup of patients.

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