Barely Significant
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Bacterial-Derived Outer Membrane Vesicles are Potent Adjuvants that Drive Humoral and Cellular Immune Responses.

Pharmaceutics · 2021 · PMC7909432 · PMID 33498352

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highly significantno p-value reported
This is highly significant because the totality of these immune responses is typically very difficult, if not impossible, to achieve without the use of a live or replicating vaccine.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.