Morphometric Analysis of Retinal Pigment Epithelial Cells From C57BL/6J Mice During Aging.

On the contrary, the estimated cell count increase rate was higher in the young group at distances between 1200 μm and 2400 μm (young, 29.8 cells/μm; old, 28.4 cells/μm), and the linear mixed model analysis showed a marginal significance in interactions between age groups and the distance from the center of the optic disc in this range (β =1.35; P = 0.068) ( Fig. 2 I).

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Peripheral Cells Grow More Than the Central Cells and Abnormally Large Cells Appear in the Central Area During Aging For young mice, the average cell size showed a decreasing trend toward the periphery; however, cells in zone 5 showed a dramatic size increase for older mice.

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