at the limit of significancep = 0.051
However, IRAK1 mRNA expression in RTT patients <15 years old was lower at the limit of significance ( p = 0.051) than in the corresponding controls, while in RTT patients >15 years old it was higher ( p = 0.028) than in the corresponding controls ( Figure 1 B), suggesting nonlinear changes in IRAK1 expression with age.