Tumor Microenvironment, HLA Class I and APM Expression in HPV-Negative Oral Squamous Cell Carcinoma.

In detail, the intensity of tumoral HLA-I HC/β 2 -m surface expression correlated highly significant positively with the density of intra-tumoral CD8 + T cells ( p = 0.008 resp. 0.003), but negatively with the number of CD8 + T cells adjacent to FoxP3 + cells within a radius of 30 μm ( p = 0.009 resp. 0.007) ( Table 5 ).

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