Novel Potent and Selective DPP-4 Inhibitors: Design, Synthesis and Molecular Docking Study of Dihydropyrimidine Phthalimide Hybrids.

Effect of Chronic Treatment of Compounds 10a–j with or without MET on HFD-Induced Type 2 Diabetic rats HFD significantly induced insulin resistance in SD rats as evident by extremely significant increase in the AUC of OGTT in non-treated diabetic group compared to control group, as shown in ( Figure 4 a,b).

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