Serum Levels of Irisin and Omentin-1 in Breast Neoplasms and Their Association with Tumor Histology.

Post hoc comparison between healthy control and chemotherapy-treated group subjects was borderline significant ( p =0.06), but significance was lost after adjustment for age ( p =0.13), and this result remained unaffected after further adjustment for Body Mass Index (BMI), serum glucose, and total cholesterol ( p for trend >0.05 for all) ( Figure 1(a) ).

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When we adjusted our analyses for omentin-1 levels, a surrogate marker of visceral obesity, the comparison between healthy controls and patients with benign tumors failed to reach significance while comparison with cancer patients was persistent, suggesting that the association between irisin concentration and presence of breast malignancy is not affected by visceral adiposity.

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