Modeling and Simulation to Support Phase Ib/IIa Dose Selection for WBP216, A Long Half-Life Fully Human Monoclonal Antibody Against Interleukin-6.

Front Pharmacol · 2021 · PMC7930490 · PMID 33679400

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a slight trendno p-value reported

Although the NCA analysis suggested a slight trend of absorption saturation, it seemed not obvious enough to fit a typical M–M equation best in absorption phase.

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an increasing trendno p-value reported

Like CL/ F , V/ F presented an increasing trend over dose levels.

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